They have discovered that a synthetically-produced chemical compound which works like the illegal drug to relieve pain could be developed as a potential treatment. The artificial compound could also reduce joint inflammation, according to new research at the Arthritis Research UK Pain Centre at the University of Nottingham. It could be five to 10 years before a pill is available for patients. But creating a drug which tackles pain long term without side effects would revolutionise the treatment of osteoarthritis.
Cannabis contains a number of natural chemicals called cannabinoids and the brain has the ability to respond to such compounds. Cannabis and synthetically manufactured cannabinoid compounds can relieve pain in animal models of arthritis, but their use has been limited because of undesirable psychological side-effects.
Now a team of researchers led by Professor Victoria Chapman at the Arthritis Research UK Pain Centre at The University of Nottingham have shown that selectively targeting one of the molecules involved in the body's natural pain-sensing pathways, called cannabinoid receptor2 (CB2) can also reduce pain in animal models of osteoarthritis. This works in part through the central nervous system (spinal cord and brain). The compound used in this study, called JWH133, is a synthetic cannabinoid molecule manufactured in a laboratory and is not derived from the cannabis plant.
When the research was extended to humans, studies of the human spinal cord tissue showed for the first …
One of marijuana’s oldest recorded uses is relieving swelling and inflammation. Currently, modern scientist are exploring a network of cannabinoid receptor sites located throughout the body. This new understandings of cannabinoid research clearly supports the historical references on treating inflammation with marijuana. Different cannabinoids founds naturally in marijuana have different benefits for arthritis sufferers. Tetrahydroconnabinol (THC) is beneficial as a pain reliever. Cannabichromene (CBC) and cannabidiol (CBD) have been shown in clinical studies to have valuable anti-inflammatory properties.
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