Probenecid is used to treat chronic gout and gouty arthritis. It is used to prevent attacks related to gout, not treat them once they occur. It acts on the kidneys to help the body eliminate uric acid. Probenecid is also used to make certain antibiotics more effective by preventing the body from passing them in the urine.This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Probenecid comes in a tablet to take by mouth. It usually is taken two times a day when prescribed for chronic gout or gouty arthritis and four times a day when prescribed with antibiotics to make them more effective. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take probenecid exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Probenecid may increase the frequency of gout attacks during the first 6 to 12 months that you take it, although it will eventually prevent them. Another drug, such as colchicine, may be prescribed to decrease this effect.
A few popular antibiotics affect DNA, similar to some chemotherapy agents. If youre sensitive to them, you could pay a neurological price that causes sudden and serious neuropathy and degrees of brain damage. The Food and Drug Administration is concerned about drugs in the fluoroquinolone class, and these already have a black box warning for an increased risk of tendon ruptures. But Im telling you that more reports have come in with accusations of neurological damage. Personally, I would only use these for life-threatening infections that were unresponsive to older, regular antibiotics. –Suzy Cohen, RPh
It is not appropriate to give people cell-destroying chemotherapy drugs when they dont have cancer. That should be obvious. It shouldnt even need to be said. But its happening every day when people are prescribed fluoroquinolone antibiotics Cipro/ciprofloxacin, Levaquin/levofloxacin, Floxin/ofloxacin andAvelox/moxifloxacin to treat ear, bladder, prostate, sinus and other …
Ciprofloxacin has been found to affect mammalian topoisomerase II, especially in mitochondria. In vitro studies in drug-treated mammalian cells found that nalidixic acid and ciprofloxacin cause a loss of motichondrial DNA (mtDNA), resulting in a decrease of mitochondrial respiration and an arrest in cell growth. Further analysis found protein-linked double-stranded DNA breaks in the mtDNA from ciprofloxacin-treated cells, suggesting that ciprofloxacin was targeting topoisomerase II activity in the mitochondria.
The FDA approved the clinical trial for Qinprezo/vosaroxin, so THEY KNOW that quinolone derivative drugs are chemotherapeutic agents.
DISREGARD OF THE HIPPOCRATIC OATH
But the FDA won’t change their prescribing guidelines based on the large amount of evidence that fluoroquinolones are cell-destroying chemo drugs. Instead, they let doctors prescribe these dangerous drugs to people who are healthy other than an infection. Cancer drugs – drugs that hurt people – are being given to formerly healthy people to get rid of prostate and sinus infections.
It’s a ridiculous and obscene violation of the Hippocratic Oath.
Because both doctors and the FDA refuse to acknowledge that fluoroquinolones are chemo drugs, not “just” antibiotics, the adverse effects of these dangerous drugs aren’t recognized. Like all cell-destroying chemo drugs, fluoroquinolone induced cellular destruction leads to increased oxidative stress which causes multi-symptom, often chronic, illnesses. Fluoroquinolone toxicity syndrome looks and feels a lot like rheumatoid arthritis, lupus, fibromyalgia, chronic fatigue syndrome / M.E., etc. The damage done to a person’s cardiovascular system by fluoroquinolones can lead to heart attacks long after exposure to the drug has stopped. The depletion of magnesium from cells by fluoroquinolones can lead to type-2 diabetes. Most ironically, drug induced cellular destruction can cause cancer.
IGNORANCE ISN’T BLISSCellular destruction by drugs leads to illness. When it’s recognized that fluoroquinolones destroy cells, the connection between them and the multi-symptom, chronic illnesses that fluoroquinolone toxicity mimics, isn’t that hard to recognize.
But rather than recognizing how fluoroquinolones work (it says right on the label that their mechanism for action is interruption of topoisomerases), they are thought of as “just” antibiotics and thus the only adverse reactions that are recognized as connected with them are allergic reactions that send people to the emergency room.
Chemo drugs have long-lasting adverse effects. Often, adverse reactions to chemo drugs are delayed. There is a tolerance threshold for chemo drugs. Adverse reactions to chemo drugs are systemic. All of these things are true for fluoroquinolones.
If you suffer from disabling peripheral neuropathy, or brain fog, or destroyed cartilage, or any of the other adverse effects of fluoroquinolones that can be explained by the fact that they are chemo drugs, you may think that justice and retribution for your pain and suffering may be gained through suing the doctor that inappropriately gave you a chemotherapeutic drug when you didn’t have cancer. Unfortunately, success with a lawsuit is unlikely because doctors are prescribing dangerous chemo drugs to generally healthy people who have infections (and even prophylactically for traveler’s diarrhea) because fluoroquinolones are approved for those uses. The FDA negligently allows cell-destroying drugs to be given to people to treat simple infections and traveler’s diarrhea. The FDA allows fluoroquinolone chemo drugs to be given to KIDS (ciprodex ear drops are approved for children as young as 6 months old).
THE FDA ISN’T PROTECTING YOU FROM CELL-DESTROYING DRUGSDo you want to take a cell destroying chemo drug when a relatively benign antibiotic in the cephalosporin or penicillin class could get rid of your infection? Do you want to give your child a chemo drug? Of course not – that’s ridiculous.
But the FDA isn’t keeping it from happening. They are looking the other way while more than 20 million prescriptions for fluoroquinolones are written each year. They aren’t making the connection between cell-destroying drugs (fluoroquinolones are a big culprit, but they’re not the only dangerous, cell-destroying drug) and the chronic diseases that plague us. They are not protecting the people from the pharmaceutical companies that want REO for their investors, not health for the world’s citizens. They are allowing the absurd situation of an acute problem – an infection – being converted into a chronic illness (fluoroquinolone toxicity syndrome and all the other diseases related to cellular destruction) by a chemo drug masquerading as an antibiotic.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to probenecid. Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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