Leukemia is cancer of the body's blood-forming tissues, including the bone marrow and the lymphatic system. Many types of leukemia exist. Some forms of leukemia are more common in children. Other forms of leukemia occur mostly in adults.
Immunosuppressive drugs called thiopurines have been found to increase the risk of myeloid disorders, such as acute myeloid leukemia and myelodysplastic syndrome, a rare bone marrow disorder, seven-fold among inflammatory bowel disease patients. IBD can negatively impact an individual's life and result in a significant amount of medical bills. Treatments for IBD vary, including: nutrition, emotional support, medical therapy and surgery.
“In order to make appropriate, informed decisions about thiopurines, patients and providers need to be well-educated about the risks and benefits of this treatment,” said study author Laurent Peyrin-Biroulet, MD, PhD, department of hepato-gastroenterology, University Hospital of Nancy-Brabois in France. “According to our research, the risk of myeloid disorders was not increased among the overall IBD population, compared with the general population, however it was increased amongst those taking thiopurines. We hope these findings encourage other researchers to investigate more about the drug and its potentially harmful effects.”
Researchers conducted a prospective observational study to determine the trends of IBD patients exposed to thiopurines. The researchers studied 19,486 patients enrolled in the Cancers Et Surrisque Associé aux Maladies inflammatoires intestinales En France study from May 2004 through June 2005. After three years of follow up, five patients were diagnosed with incident myeloid disorders.
Four of these patients had been previously exposed to …
IBD can negatively impact an individual's life and result in a significant amount of medical bills. Treatments for IBD vary and your doctor can discuss the following options with you: nutrition, emotional support, medical therapy and surgery.
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