A study led by a Rutgers University research team finds that the commonly used pesticide deltamethrin increases the risk of attention deficit hyperactivity disorder (ADHD) in children, adding to a mounting body of scientific research linking pesticide exposure to the disorder. Rutgers scientists, along with colleagues from Emory University, the University of Rochester Medical Center, and Wake Forest University discovered that mice exposed to the pyrethroid insecticide deltamethrin in utero and through lactation exhibit several features of ADHD, including dysfunctional dopamine signaling in the brain, hyperactivity, working memory, attention deficits and impulsive-like behavior. The study, Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder, was published Wednesday in the Journal of the Federation of American Societies for Experimental Biology (FASEB).
ADHD is estimated to affect 8–12% of school-age children worldwide. ADHD is a complex disorder, and though is strong scientific evidence that genetics play a role in susceptibility to the disorder, no specific gene has been found that causes ADHD and scientists believe that environmental factors, such as pesticide exposure, may contribute to the development of the behavioral condition.
A commonly used pesticide may alter the development of the brain's dopamine system — responsible for emotional expression and cognitive function – and increase the risk of attention deficit hyperactivity disorder in children, according to a new Rutgers study.
The research published Wednesday in the Journal of the Federation of American Societies for Experimental Biology (FASEB), by Rutgers scientists and colleagues from Emory University, the University of Rochester Medical Center, and Wake Forest University discovered that mice exposed to the pyrethroid pesticide deltamethrin in utero and through lactation exhibited several features of ADHD, including dysfunctional dopamine signaling in the brain, hyperactivity, working memory, attention deficits and impulsive-like behavior.
These findings provide strong evidence, using data from animal models and humans, that exposure to pyrethroid pesticides, including deltamethrin, may be a risk factor for ADHD, says lead author Jason Richardson, associate professor in the Department and Environmental and Occupational Medicine at Rutgers Robert …
The study also analyzed health care questionnaires and urine samples of 2,123 children and adolescents using data from the Centers for Disease Control, National Health and Nutrition Examination Survey (NHANES). By cross-referencing prescription drug history and parental reports of ADHD diagnoses, the researchers determined that children with higher pyrethroid pesticide metabolite levels in their urine were more than twice as likely to be diagnosed with the disorder.
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