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New research published in Diabetologia (the journal of the European Association for the Study of Diabetes) shows that calcium and vitamin D supplementation improves the metabolic profile of pregnant women with gestational diabetes.
Simply supplementing with calcium and vitamin D couldhelp treat a tricky problem in pregnant women.
Gestational diabetes mellitus (GDM), which can occur in as many as 14% of all pregnancies, is characterized by carbohydrate intolerance and metabolic disorders. It is more common in women who are overweight and can increase the risk of pre-eclampsia, pre-term delivery and delivery by caesarean section.
“We are aware of no study that has examined the effect of joint calcium-vitamin D supplementation on insulin function, lipid profiles, inflammatory factors and biomarkers of oxidative stress in GDM,” say the authors. “The current study was, therefore, done to investigate the effects of calcium plus vitamin D supplementation on metabolic status of pregnant women with GDM.”
Metabolic improvements
The supplemented group showed significant reductions in fasting plasma glucose, insulin, and LDL or ‘bad’ cholesterol, as well as improvements in insulin sensitivity and increases in HDL or ‘good’ cholesterol, compared with those patients …
“Calcium plus vitamin D supplementation in GDM women had beneficial effects on metabolic profile…this is important because elevated circulating levels of inflammatory markers and impaired insulin metabolism in GDM can predict the progression to type 2 diabetes…later in life and neonatal complications. Impaired insulin metabolism in women with GDM can result in adverse long term maternal outcomes and increased perinatal morbidity (babies large for gestational age, birth trauma, pre-eclampsia), and long-term consequences in the offspring. In addition, increased inflammatory markers in GDM might predict the future development of both metabolic and cardiovascular disease,” the authors said in a news release. In addition to such limitations as loss to follow-up, the authors did not assess the effects of supplemental vitamin D and calcium and ultimate pregnancy outcomes.
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