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The importance of vitamin D for cardiovascular health has been the focus of increasing interest. Low levels of vitamin D have previously been shown to be related to increased risk of stroke and heart attack. Vitamin D deficiency and insufficiency are highly prevalent among children worldwide, and this study examined the relationship between low childhood vitamin D levels and adult increased carotid intima-thickness (IMT). IMT is a marker of structural atherosclerosis, which correlates with cardiovascular risk factors, and predicts cardiovascular events.
The importance of vitamin D for cardiovascular health has been the focus of increasing interest. Low levels of vitamin D have previously been shown to be related to increased risk of stroke and heart attack. Now new evidence shows that not getting enough as a child could raise the risk of heart disease later in life.
Vitamin D deficiency and insufficiency are highly prevalent among children worldwide, and this study examined the relationship between low childhood vitamin D levels and adult increased carotid intima-thickness (IMT). IMT is a marker of structural atherosclerosis, which correlates with cardiovascular risk factors, and predicts cardiovascular events.
This study analyzed 2,148 subjects from the Cardiovascular Risk in Young Finns Study, aged 3-18 years at baseline. Subjects were re-examined at age 30-45 years. Childhood levels of vitamin D were measured from stored serum. Blood levels of vitamin D were measured using a standard 25-hydroxy vitamin D blood test.
Carotid …
The study had several major strengths. The large randomized sample population permits more powerful results. Also, the participants were followed for a long duration. Lastly, the researchers collected extensive data on potential confounding factors.
There were also important limitations to note. The study population was comprised of young adults, so they were unable to associate cardiovascular events with vitamin D status. In addition, the study only included Finnish participants, which limits the generalizability of the results.
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